Albinism Research Today is a free monthly online journal that collates and summarizes the latest research about Albinism, including details on pigmentation, genetic trait, heritability.

"Out, damned spot!".

Spritz RA

Human Medical Genetics Program, University of Colorado Health Sciences Center, Mail-stop 8300, PO Box 6511, Aurora, CO 80045, USA. richard.spritz@uchsc.edu

Mice transgenic for the Kit Val620Ala mutation, which in humans has been associated with progressive piebaldism, exhibit dominant white spotting but show no evidence of progressive depigmentation. These results are consistent with the previous hypothesis that progressive piebaldism might result from digenic inheritance, of the KIT(V620A) mutation that causes piebaldism and a second, unknown locus that causes progressive depigmentation.

Published 18 April 2006 in J Invest Dermatol, 126(5): 949-51.
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